Santa Cruz is a Chilean city and commune, located in the Colchagua valley, in the O'Higgins Region, located on the southern shore of the Tinguiriri…Santa Cruz is a Chilean city and commune, located in the Colchagua valley, in the O'Higgins Region, located on the southern shore of the Tinguiririca river, 110 miles from Santiago, Chile's capital city, and 27 miles from San Fernando.