rmdopen.bmj6d
Window of opportunity in rheumatoid arthritis – definitions and supporting evidence: from old to new perspectives
The therapeutic window of opportunity in rheumatoid arthritis (RA) is often referred to. However, some have questioned whether such a period, in which the disease is more susceptible to ...
rmdopen.bmj10d
Novel insight into the aetiology of rheumatoid arthritis gained by a cross-tissue transcriptome-wide association study
Background Although genome-wide association studies (GWASs) have identified more than 100 loci associated with rheumatoid arthritis (RA) susceptibility, the causal genes and biological mechanisms ...
rmdopen.bmj12d
Disease response in rheumatoid arthritis across four biologic therapies associates with improvement in paraoxonase-1 activity and oxylipins
Objective Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme, that has been implicated as a biomarker of cardiovascular risk in patients with rheumatoid arthritis (RA). We ...
rmdopen.bmj5d
Large language model-driven sentiment analysis for facilitating fibromyalgia diagnosis
Background Fibromyalgia (FM) is a complex disorder with widespread pain and emotional distress, posing diagnostic challenges. FM patients show altered cognitive and emotional processing, with a ...
rmdopen.bmj13d
Efficacy and safety of filgotinib in patients with rheumatoid arthritis: week 156 interim results from a long-term extension study
Background Janus kinase inhibitors are an effective option for achieving sustained remission or low disease activity in patients with rheumatoid arthritis (RA) following inadequate response to ...
rmdopen.bmj9d
Physical workload is associated with increased risk of rheumatoid arthritis: results from a Swedish population-based case–control study
Objectives This study investigated: (1) the association of physical workload (PW) and risk of rheumatoid arthritis (RA); (2) the potential interactions between PW and the genes in the human leucocyte ...
rmdopen.bmj13d
Time trends in the burden of autoimmune diseases across the BRICS: an age–period–cohort analysis for the GBD 2019
Background This study aims to evaluate the long-term trend of prevalence and DALY (disability-adjusted life-year) rate on the age, period and cohort (APC) of the BRICS (Brazil, Russia, India, China ...
rmdopen.bmj4d
Diagnosis challenges in inception cohorts in axial spondyloarthritis: the case of the French national DESIR cohort
Background Inception cohorts aim to describe chronic diseases from diagnosis and over years of follow-up. Axial spondyloarthritis (axSpA) diagnosis might be challenging during the first years of the ...
rmdopen.bmj8d
Long-term efficiency of infliximab in patients with ankylosing spondylitis: real life data confirm the potential for dose reduction
Objective To analyse the treatment outcome of patients with ankylosing spondylitis (AS) in the European AS infliximab cohort (EASIC) study after a total period of 8 years with specific focus on dosage ...
rmdopen.bmj8d
Synovial fibroblasts in 2017
Stromal cells like synovial fibroblasts gained great interest over the years, since it has become clear that they strongly influence their environment and neighbouring cells. The current review ...
rmdopen.bmj9d
Association between musculoskeletal sonographic features and response to treatment in patients with psoriatic arthritis
Objective To investigate the association between musculoskeletal sonographic features and clinical features, as well as treatment outcomes, in patients with active psoriatic arthritis (PsA). Methods A ...
rmdopen.bmj7d
The effect of tofacitinib on residual pain in patients with rheumatoid arthritis and psoriatic arthritis
Objective Post hoc analysis of pooled data from nine randomised controlled trials to assess the effect of tofacitinib (oral Janus kinase inhibitor for treatment of rheumatoid arthritis (RA) and ...