Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking ...

Hereditary angioedema is a rare genetic disease characterized by severe and unpredictable swelling attacks. NTLA-2002 is an in vivo gene-editing therapy that is based on clustered regularly ...

In the active trial, patients with chronic kidney disease were randomly assigned to receive either empagliflozin (10 mg once daily) or matching placebo and were followed for a median of 2 years ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double ...

Resistance to third-generation EGFR-TKIs develops in nearly all patients with EGFR–mutated non–small-cell lung cancer. First-line treatment with amivantamab–lazertinib may improve clinical ...

As limits on access to gender-transition–related health care increase, it’s helpful to contextualize the shift in terms of historical characterizations and fears of sexual and gender minority ...

Hairy-cell leukemia (HCL) is a rare, indolent neoplasm of mature B cells with hairlike surface projections that circulate in the blood and preferentially infiltrate the bone marrow and spleen.

Limited fasciectomy is the method most frequently used to correct Dupuytren’s contracture in Europe and the United States. 5-7 Another treatment involves injection of an enzyme, collagenase ...

Kidney transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV is an emerging practice. It has been performed since 2016 under the U.S. congressional HIV Organ ...

Dr. Danielle C. Crabtree (Medicine): A 37-year-old man was admitted to this hospital because of fever, myalgia, jaundice, and hypoxemia. The patient had been healthy until 9 days before this ...

Dr. Lucas X. Marinacci: A 72-year-old woman was evaluated for dysarthria and respiratory failure during an admission to this hospital, which had occurred before the coronavirus disease 2019 pandemic.

Combination chemotherapy has been the standard treatment for advanced-stage Hodgkin’s lymphoma for decades. Chemotherapy backbones differ worldwide, with doxorubicin, bleomycin, vinblastine, and ...