Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking ...

Artificial Intelligence (AI) has tremendous potential to advance clinical practice and the delivery of patient care. A new Review article series, “AI in Medicine,” explores the role of AI ...

Patients with IgA nephropathy and severe proteinuria have a high lifetime risk of kidney failure. The efficacy and safety of the selective endothelin type A receptor antagonist atrasentan in ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double ...

In the active trial, patients with chronic kidney disease were randomly assigned to receive either empagliflozin (10 mg once daily) or matching placebo and were followed for a median of 2 years ...

Hereditary angioedema is a rare genetic disease characterized by severe and unpredictable swelling attacks. NTLA-2002 is an in vivo gene-editing therapy that is based on clustered regularly ...

As limits on access to gender-transition–related health care increase, it’s helpful to contextualize the shift in terms of historical characterizations and fears of sexual and gender minority ...

Jose Figueroa is an associate professor of health policy and management at the Harvard T.H. Chan School of Public Health and an assistant professor of medicine at Harvard Medical School.

Kidney transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV is an emerging practice. It has been performed since 2016 under the U.S. congressional HIV Organ ...

Dr. Lucas X. Marinacci: A 72-year-old woman was evaluated for dysarthria and respiratory failure during an admission to this hospital, which had occurred before the coronavirus disease 2019 pandemic.

Combination chemotherapy has been the standard treatment for advanced-stage Hodgkin’s lymphoma for decades. Chemotherapy backbones differ worldwide, with doxorubicin, bleomycin, vinblastine, and ...

Whether stereotactic body radiotherapy (SBRT) is noninferior to conventionally or moderately hypofractionated regimens with respect to biochemical or clinical failure in patients with localized ...