The most commonly prescribed topical antibiotic for stye is erythromycin. Oral antibiotics are more effective, usually amoxicillin, cephalosporin, tetracycline, doxycycline, or erythromycin. The stye should clear in about two days, but the antibiotic should be taken for the full term prescribed, usually seven days.

Use an over-the-counter treatment. Try an ointment (such as Stye), solution (such as Bausch and Lomb Eye Wash), or medicated pads (such as Ocusoft Lid Scrub). Let the stye or chalazion open on its own. Don't squeeze or open it. Don't wear eye makeup or contact lenses until the area has healed.